cPanel offer two FTP servers to choose with. PureFTP and ProFTP - the default one is pure FTP. If you want to make a change, you can do this from WHM Main >> Service Configuration >> FTP Server Selection.
cPanel offers you two mail servers, Courier and Dovecot. It can be selected from WHM Main >> Service Configuration >> Mailserver Selection. Additionally, you may disable IMAP and POP3 servers.
RBL stands for Realtime Black lists and it mainly works for email servers. RBL is a collections of IP addresses or network addresses which has been found to be spamming. So the email servers will connect to these RBLs before accepting email from an IP and make sure that the IP from with the mail arrives is free from spams.
Keeping MySQL on the server up to date is essential for the efficiency of codes . There are times when we just cannot let cPanel handle an upgrade because we may end up having our databases not working properly after an upgrade. So, therefore we need to do upgrades of MySQL manually.
Change default FTP port for greater security for the server and to its contents, if the server is a shared one. Not only because the default port gives you a connection automatically and if they could guess the password, your content is in risk. So, I would suggesto to change the FTP port to a non standard one.